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This meeting took place in 2019
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Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment (M2)
Organizer(s) Erika L. Pearce, Sarah-Maria Fendt, Russell G. Jones and Peter F. Carmeliet
March 15—19, 2019
Firenze Fiera- Fortezza da Basso • Florence, Italy
Discounted Abstract Deadline: Nov 28, 2018
Abstract Deadline: Dec 11, 2018
Scholarship Deadline: Nov 28, 2018
Discounted Registration Deadline: Jan 17, 2019
Organized in collaboration with the following organizations - Cancer Research UK and Menarini International Foundation
Sponsored by Autolus Therapeutics
Sponsored by Autolus Therapeutics
Summary of Meeting:
In disease states, immune cells must compete for available resources to control tissue homeostasis or mediate protective functions. This is particularly true in cancer, where rapidly proliferating and metabolically dysregulated tumors exert metabolic pressure on cells within the tumor microenvironment. Understanding how immune and non-immune cells respond to these conditions and restrain tumor growth and metastasis is critical for developing new cancer therapies. Often cancer biologists and immunologists have little crossover, and this presents a significant barrier to furthering knowledge. This interdisciplinary conference brings together immunologists and scientists focusing on cancer to reveal novel and integrated mechanistic underpinnings that lead to cancer progression/regression and metastasis. Our goals are to: Integrate cancer biologists and immunologists who have a common interest in how cellular metabolism influences cell function; raise awareness of the metabolic intersection between tumor biology and immunology; and encourage junior researchers to actively participate at this interface. Attendees will leave the conference with a stronger understanding of how metabolism in immune cells and non-immune cells influence cell function in metastasis and the tumor microenvironment. We hope that researchers from cancer biology and immunology will, as a result of their interactions, forge new collaborations founded in their mutual appreciation that engagement of particular metabolic pathways shapes cell function and fate. Given the resurgence that metabolism has seen in recent years, we think our conference will appeal broadly to many researchers across cancer biology and immunology, many of whom are interested in investigating metabolic changes in their particular systems.
View Scholarships/Awards
In disease states, immune cells must compete for available resources to control tissue homeostasis or mediate protective functions. This is particularly true in cancer, where rapidly proliferating and metabolically dysregulated tumors exert metabolic pressure on cells within the tumor microenvironment. Understanding how immune and non-immune cells respond to these conditions and restrain tumor growth and metastasis is critical for developing new cancer therapies. Often cancer biologists and immunologists have little crossover, and this presents a significant barrier to furthering knowledge. This interdisciplinary conference brings together immunologists and scientists focusing on cancer to reveal novel and integrated mechanistic underpinnings that lead to cancer progression/regression and metastasis. Our goals are to: Integrate cancer biologists and immunologists who have a common interest in how cellular metabolism influences cell function; raise awareness of the metabolic intersection between tumor biology and immunology; and encourage junior researchers to actively participate at this interface. Attendees will leave the conference with a stronger understanding of how metabolism in immune cells and non-immune cells influence cell function in metastasis and the tumor microenvironment. We hope that researchers from cancer biology and immunology will, as a result of their interactions, forge new collaborations founded in their mutual appreciation that engagement of particular metabolic pathways shapes cell function and fate. Given the resurgence that metabolism has seen in recent years, we think our conference will appeal broadly to many researchers across cancer biology and immunology, many of whom are interested in investigating metabolic changes in their particular systems.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Friday, March 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 19 with a closing plenary session from 16:00 to 18:00, followed by a social hour and entertainment. We recommend return travel on Wednesday, March 20 in order to fully experience the meeting.
FRIDAY, MARCH 15
SATURDAY, MARCH 16
SUNDAY, MARCH 17
MONDAY, MARCH 18
TUESDAY, MARCH 19
WEDNESDAY, MARCH 20
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Friday, March 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 19 with a closing plenary session from 16:00 to 18:00, followed by a social hour and entertainment. We recommend return travel on Wednesday, March 20 in order to fully experience the meeting.
FRIDAY, MARCH 15
16:00—20:00
Arrival and Registration
Fureria
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
Arsenale
08:00—08:30
Poster Setup
Arsenale
08:30—18:00
Poster Viewing
Arsenale
08:30—09:30
Welcome and Keynote Address
Meeting has ended...abstracts no longer viewable online.
Basilica
*
Erika L. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Charles Swanton,
Francis Crick Institute, UK
Chromosomal Instability and Genome Plasticity in Cancer Evolution, Immune Evasion and Metastasis
Chromosomal Instability and Genome Plasticity in Cancer Evolution, Immune Evasion and Metastasis
09:30—12:00
Interactions via the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.
Basilica
*
Sarah-Maria Fendt,
VIB Leuven, Belgium
Massimiliano Mazzone,
KU Leuven – VIB, Belgium
Immunometabolism in Cancer and Other Diseases
Immunometabolism in Cancer and Other Diseases
Coffee Break
Shizhen Emily Wang,
University of California, San Diego, USA
Secreted miRNAs Reprogram Metabolism in the Tumor Niche
Secreted miRNAs Reprogram Metabolism in the Tumor Niche
Karen H. Vousden,
Francis Crick Institute, UK
ROS Regulation and Cancer Progression
ROS Regulation and Cancer Progression
Samuel F. Bakhoum,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Chromosomal Instability Promotes Metastasis through a Cytosolic DNA Response and Modulation of the Immune Microenvironment
Short Talk: Chromosomal Instability Promotes Metastasis through a Cytosolic DNA Response and Modulation of the Immune Microenvironment
Li Yang,
NCI, National Institutes of Health, USA
Short Talk: DNMT3B Induction at Distant Site Promotes Breast Cancer Metastasis through Epigenetic Reprogramming
Short Talk: DNMT3B Induction at Distant Site Promotes Breast Cancer Metastasis through Epigenetic Reprogramming
12:00—13:00
Lunch
Arsenale
13:00—15:30
Poster Session 1
Arsenale
15:30—16:00
Coffee Available
Arsenale
16:00—18:00
Mitochondria and Oxidative Stress in Cancer Metastasis and Immunity
Meeting has ended...abstracts no longer viewable online.
Basilica
*
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Erika L. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Mitochondrial Integrity Regulated by FABP5 is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
Mitochondrial Integrity Regulated by FABP5 is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
Marcia C. Haigis,
Harvard Medical School, USA
New Functions for Metabolic Byproducts in the Tumor Microenvironment
New Functions for Metabolic Byproducts in the Tumor Microenvironment
Russell G. Jones,
Van Andel Research Institute, USA
Essential Nutrients for Effector T Cell Expansion
Essential Nutrients for Effector T Cell Expansion
Zachary T. Schafer,
University of Notre Dame, USA
Short Talk: Resistance to PD-1 Checkpoint Inhibitors Is Associated with Defective RIPK1-Mediated Mitophagy
Short Talk: Resistance to PD-1 Checkpoint Inhibitors Is Associated with Defective RIPK1-Mediated Mitophagy
Alexei Vazquez,
CRUK Beatson Institute, UK
Short Talk: Formate Links Glycolysis to Oxidative Phosphorylation
Short Talk: Formate Links Glycolysis to Oxidative Phosphorylation
18:00
On Own for Dinner
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Cancer and Immunity in the Tumor Microenvironment
Meeting has ended...abstracts no longer viewable online.
Basilica
*
Georgia Hatzivassiliou,
Genentech, Inc., USA
Ralph J. DeBerardinis,
University of Texas Southwestern Medical Center, USA
Metabolic Enablers of Cancer Progression
Metabolic Enablers of Cancer Progression
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Microenvironmental Determinants of Tumor Metabolism
Microenvironmental Determinants of Tumor Metabolism
Coffee Break
Giuseppe Matarese,
Università degli Studi di Napoli Federico II, Italy
Regulatory T Cells as Suppressors of Anti-Tumor Immunity
Regulatory T Cells as Suppressors of Anti-Tumor Immunity
Iannis Aifantis,
New York University School of Medicine, USA
Mapping the Bone Marrow Microenvironment in Single Cell Resolution
Mapping the Bone Marrow Microenvironment in Single Cell Resolution
Fabio Grassi,
Institute for Research in Biomedicine, Switzerland
Short Talk: Senescence Induction by the ATP-Gated P2X7 Receptor Limits T Cell Effector Response in the Tumor Microenvironment
Short Talk: Senescence Induction by the ATP-Gated P2X7 Receptor Limits T Cell Effector Response in the Tumor Microenvironment
Paula D. Bos,
Virginia Commonwealth University, USA
Short Talk: Regulatory T Cells Promote Breast Cancer Progression and Metastasis by Functional Reprogramming of Bone Marrow-Derived Cell Populations
Short Talk: Regulatory T Cells Promote Breast Cancer Progression and Metastasis by Functional Reprogramming of Bone Marrow-Derived Cell Populations
Zachary Bacigalupa,
Vanderbilt University Medical Center, USA
Short Talk: Targeting ACSS2 Inhibits HIF-2α Signaling in ccRCC and Promotes Favorable T Cell Characteristics Immune Response in ccRCC
Short Talk: Targeting ACSS2 Inhibits HIF-2α Signaling in ccRCC and Promotes Favorable T Cell Characteristics Immune Response in ccRCC
11:45—16:00
On Own for Lunch
11:45—13:00
Poster Setup
Arsenale
13:00—22:00
Poster Viewing
Arsenale
13:30—15:30
Workshop
Basilica
*
Julian J. Lum,
British Columbia Cancer Agency, Canada
Ho-Young Lee,
Seoul National University, South Korea
The Interplay between Slow-Cycling Chemoresistant Cancer Cells and Fibroblasts in Tumor Microenvironment Mediates Tumor Recurrence in Lung Cancer
The Interplay between Slow-Cycling Chemoresistant Cancer Cells and Fibroblasts in Tumor Microenvironment Mediates Tumor Recurrence in Lung Cancer
Julianna Blagih,
Francis Crick Institute, UK
Loss of p53 in Tumor Cells Promotes Immune-Tolerance through Modulation of the Innate and Adaptive Immune Responses
Loss of p53 in Tumor Cells Promotes Immune-Tolerance through Modulation of the Innate and Adaptive Immune Responses
Medhi Wangpaichitr,
Miami VA Hospital, USA
Kynurenine Metabolism in Cisplatin-Resistant Lung Cancer
Kynurenine Metabolism in Cisplatin-Resistant Lung Cancer
Nuzhat Ahmed,
Fiona Elsey Cancer Research Institute, Australia
Metabolic and Immune Regulatory Signatures in Chemoresistant Ovarian Cancer Stem Cells
Metabolic and Immune Regulatory Signatures in Chemoresistant Ovarian Cancer Stem Cells
David R. Soto-Pantoja,
Wake Forest School of Medicine, USA
Metabolic Endpoints as Biomarkers of Immune Checkpoint Therapy Response
Metabolic Endpoints as Biomarkers of Immune Checkpoint Therapy Response
Chia-Ning Shen,
Academia Sinica, Taiwan
Mitochondrial OXPHOS Activity Is Required for Lung Metastatic Colonization of Pancreatic Cancer
Mitochondrial OXPHOS Activity Is Required for Lung Metastatic Colonization of Pancreatic Cancer
Madhusudhanan Sukumar,
NCI, National Institutes of Health, USA
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates T Cell Longevity and Anti-Tumor Function
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates T Cell Longevity and Anti-Tumor Function
Jing Fan,
University of Wisconsin-Madison, USA
Two-Stage Remodeling of Mitochondrial Metabolism in Macrophages Over a Course of Immune Response
Two-Stage Remodeling of Mitochondrial Metabolism in Macrophages Over a Course of Immune Response
15:30—16:00
Coffee Available
Arsenale
16:00—18:00
Metastasis, Tumor Vessels and Immunity
Meeting has ended...abstracts no longer viewable online.
Basilica
*
Massimiliano Mazzone,
KU Leuven – VIB, Belgium
Michael Potente,
Max Planck Institute for Heart and Lung Research, Germany
Metabolic Activity and Growth State in the Vascular Endothelium
Metabolic Activity and Growth State in the Vascular Endothelium
Sophia Y. Lunt,
Michigan State University, USA
Short Talk: Sialic Acid Metabolism Is a Key Driver of Breast Cancer Metastasis
Short Talk: Sialic Acid Metabolism Is a Key Driver of Breast Cancer Metastasis
Andreas Fischer,
German Cancer Research Center, Germany
Short Talk: Angiocrine Signals Promote Metastasis
Short Talk: Angiocrine Signals Promote Metastasis
18:00—19:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Arsenale
18:30—21:00
Poster Session 2
Arsenale
08:00—08:30
Poster Setup
Arsenale
08:30—16:00
Poster Viewing
Arsenale
08:30—11:45
Therapeutic Strategies for Metabolism and Immune Modulation
Meeting has ended...abstracts no longer viewable online.
Basilica
*
Giuseppe Matarese,
Università degli Studi di Napoli Federico II, Italy
Katya Marjon,
Agios Pharmaceuticals, USA
Therapeutics Targets in Cancer Metabolism
Therapeutics Targets in Cancer Metabolism
Coffee Break
Georgia Hatzivassiliou,
Genentech, Inc., USA
Dissecting the Impact of NRF2 Activation on Lung Adenocarcinoma Biology, Immune Contexture and Patient Outcomes
Dissecting the Impact of NRF2 Activation on Lung Adenocarcinoma Biology, Immune Contexture and Patient Outcomes
Gabriele A.I. Bergers,
University of Leuven, Belgium
Constructing Tumor Vessels to Enhance Immunity
Constructing Tumor Vessels to Enhance Immunity
Julian J. Lum,
British Columbia Cancer Agency, Canada
Short Talk: Understanding the Metabolome of Human TIL for Cancer Immunotherapy
Short Talk: Understanding the Metabolome of Human TIL for Cancer Immunotherapy
Fabricio Loayza-Puch,
German Cancer Research Center, Germany
Short Talk: Targeting Proline Availability in Metastatic Breast Cancer
Short Talk: Targeting Proline Availability in Metastatic Breast Cancer
Gus Zeiner,
Chimera Bioengineering, USA
Short Talk: A Metabolism-Triggered, Localized Payload Delivery System for T Cell Therapies
Short Talk: A Metabolism-Triggered, Localized Payload Delivery System for T Cell Therapies
11:45—13:00
Lunch
Arsenale
13:00—15:30
Poster Session 3
Arsenale
15:30—16:00
Coffee Available
Arsenale
16:00—18:00
Stem Cells in Inflammation, Cancer and Metastasis
Meeting has ended...abstracts no longer viewable online.
Basilica
*
Iannis Aifantis,
New York University School of Medicine, USA
Elaine V. Fuchs,
Rockefeller University, USA
Skin Stem Cells in Inflammation and Cancer
Skin Stem Cells in Inflammation and Cancer
Mohamed Bentires-Alj,
University of Basel, University Hospital Basel, Switzerland
Cancer Targeted Therapy and Tumor Heterogeneity: Act Locally, Think Globally
Cancer Targeted Therapy and Tumor Heterogeneity: Act Locally, Think Globally
Robert A. Weinberg,
Massachusetts Institute of Technology, USA
The EMT, Cancer and the Stem Cell State
The EMT, Cancer and the Stem Cell State
Guy Roukens,
University Medical Center Utrecht, Netherlands
Short Talk: SOX4 is Required for Regulation of Angiogenesis and Tumor Stem Cells in Breast Cancer
Short Talk: SOX4 is Required for Regulation of Angiogenesis and Tumor Stem Cells in Breast Cancer
Binwu Tang,
NCI, National Institutes of Health, USA
Short Talk: Elucidating the Role of Breast Cancer Stem Cells in Early Metastasis through Direct Visualization and Quantitation
Short Talk: Elucidating the Role of Breast Cancer Stem Cells in Early Metastasis through Direct Visualization and Quantitation
18:00
On Own for Dinner
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Metabolism Meets Cancer Metastasis
Meeting has ended...abstracts no longer viewable online.
Basilica
*
Michael Potente,
Max Planck Institute for Heart and Lung Research, Germany
M. Celeste Simon,
University of Pennsylvania, USA
Metabolic Symbioses in the Tumor Micorenvironment
Metabolic Symbioses in the Tumor Micorenvironment
Sohail F. Tavazoie,
Rockefeller University, USA
Innate Immune and Metabolic Regulation of Metastatic Progression
Innate Immune and Metabolic Regulation of Metastatic Progression
Coffee Break
Wanjun Chen,
NIDCR, National Institutes of Health, USA
D-mannose in Autoimmunity and Cancer
D-mannose in Autoimmunity and Cancer
Arkaitz Carracedo,
Center for Cooperative Research in Biosciences, Spain
Signaling and Metabolic Plasticity in the Process of Prostate Cancer Metastasis
Signaling and Metabolic Plasticity in the Process of Prostate Cancer Metastasis
Ana Patricia Gomes,
Weill Cornell Medicine, USA
Short Talk: Age-Induced Methylmalonic Acid Accumulation Promotes Cancer Progression and Metastasis Formation
Short Talk: Age-Induced Methylmalonic Acid Accumulation Promotes Cancer Progression and Metastasis Formation
Emily Jane Kay,
Beatson Institute, UK
Short Talk: Pyruvate Dehydrogenase: The Key to Epigenetic Regulation of Mammary CAFs
Short Talk: Pyruvate Dehydrogenase: The Key to Epigenetic Regulation of Mammary CAFs
Yulia Panina,
Francis Crick Institute, UK
Short Talk: Using Mass Spectrometry Imaging to Identify Metabolic Adaptations during Metastasis of MYC-Driven Tumors
Short Talk: Using Mass Spectrometry Imaging to Identify Metabolic Adaptations during Metastasis of MYC-Driven Tumors
11:45—17:00
On Own for Lunch
15:30—16:00
Coffee Available
Arsenale
16:00—17:45
Commensal Interactions: Implications for Immunity and Cancer
Meeting has ended...abstracts no longer viewable online.
Basilica
*
Russell G. Jones,
Van Andel Research Institute, USA
Filipe J. Gomes Cabreiro,
Imperial College London, UK
Host-Microbe-Drug-Nutrient Interactions- A Holistic Approach for Cancer Treatment
Host-Microbe-Drug-Nutrient Interactions- A Holistic Approach for Cancer Treatment
Jennifer Ann Wargo,
University of Texas MD Anderson Cancer Center, USA
The Gut Microbiome and PD-1 Therapy in Melanoma
The Gut Microbiome and PD-1 Therapy in Melanoma
Nicholas Chia,
Mayo Clinic, USA
Distinct Microbes, Metabolites and Ecologies Define the Microbiome in Deficient and Proficient Mismatch Repair Colorectal Cancers
Distinct Microbes, Metabolites and Ecologies Define the Microbiome in Deficient and Proficient Mismatch Repair Colorectal Cancers
17:45—18:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
Basilica
18:00—19:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Arsenale
19:00—22:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Arsenale
Departure
*Session Chair †Invited, not yet responded.
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