Firenze Fiera- Fortezza da Basso Floorplan
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Twitter hashtag for this meeting: #KSmetastasis
Cancer Metastasis: The Role of Metabolism, Immunity and the Microenvironment (M2)
Scientific Organizers: Erika L. Pearce, Sarah-Maria Fendt, Russell G. Jones and Peter F. Carmeliet
March 15—19, 2019
Firenze Fiera- Fortezza da Basso, Florence, Italy
Organized in collaboration with the following organizations - Cancer Research UK and Menarini International Foundation
Sponsored by Autolus Therapeutics
Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Deadline: Nov 28, 2018 [details]
Discounted Abstract Deadline: Nov 28, 2018 [details]
Abstract Deadline: Dec 11, 2018 [details]
Discounted Registration Deadline: Jan 17, 2019 [details]
If you have missed a deadline due to the US government shutdown, please contact our office.
Click here to view Cancellation Policy
Discounted Abstract Deadline: November 28, 2018
*All deadlines end at 11:59 PM US Mountain Standard TimeAbstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register
Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.
Submitting your abstract early allows us to:
- submit your abstract to organizers to be considered for a short talk
- accept your abstract online
- include your abstract on our website and in our secure mobile app
- reserve your space at the meeting for a poster presentation.**
(The Abstract Deadline: is December 11, 2018)
Global Health Travel Award Deadline:
*All deadlines end at 11:59 PM US Mountain Standard Time
Global Health Travel Award Details:
You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline
and complete the other required steps (verify your contact information and submit a recommendation letter)
to be considered for a travel award.
Click here to learn more about Global Health Travel Awards.
Scholarship Deadline: November 28, 2018
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Details:
You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.
Abstract Deadline: December 11, 2018
*All deadlines end at 11:59 PM US Mountain Standard Time
Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register
Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.
Submitting your abstract by the Abstract Deadline allows us to:
- submit your abstract to organizers to be considered for a short talk
- include your abstract on our website and in our secure mobile app
- reserve your space at the meeting for a poster presentation.**
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.
(Discounted Abstract Deadline: is November 28, 2018)
Discounted Registration Deadline: January 17, 2019
*All deadlines end at 11:59 PM US Mountain Standard Time
Registration Fee: 945.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 720.00 USD* (must complete student verification form)
*Includes 50.00 USD of your abstract submission fee
After the Discounted Registration Deadline:
Registration Fee: 1145.00 USD*
Student Registration Fee: 920.00 USD* (must complete student verification form)
*Includes 50.00 USD of your abstract submission fee
Registration spaces are limited and may fill prior to discounted registration deadline.
We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report any calls or correspondence you might have received to Keystone Symposia and book only through lodging links in your Keystone Symposia account, an established travel agency or directly with the hotel(s) listed on our website.
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Friday, March 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Tuesday, March 19 with a closing plenary session from 16:00 to 18:00, followed by a social hour and entertainment. We recommend return travel on Wednesday, March 20 in order to fully experience the meeting.
FRIDAY, MARCH 15
Chromosomal Instability and Genome Plasticity in Cancer Evolution, Immune Evasion and Metastasis
Registered attendees can view abstracts starting on 02/15/2019
Immunometabolism in Cancer and Other Diseases
Secreted miRNAs Reprogram Metabolism in the Tumor Niche
ROS Regulation and Cancer Progression
Short Talk: Chromosomal Instability Promotes Metastasis through a Cytosolic DNA Response and Modulation of the Immune Microenvironment
Short Talk: DNMT3B Induction at Distant Site Promotes Breast Cancer Metastasis through Epigenetic Reprogramming
Registered attendees can view abstracts starting on 02/15/2019
Mitochondrial Integrity Regulated by FABP5 is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
New Functions for Metabolic Byproducts in the Tumor Microenvironment
Metabolic Enablers of Cancer Progression
Short Talk: Resistance to PD-1 Checkpoint Inhibitors Is Associated with Defective RIPK1-Mediated Mitophagy
Short Talk: Formate Links Glycolysis to Oxidative Phosphorylation
Registered attendees can view abstracts starting on 02/15/2019
Essential Nutrients for Effector T Cell Expansion
Microenvironmental Determinants of Tumor Metabolism
Regulatory T Cells as Suppressors of Anti-Tumor Immunity
Mapping the Bone Marrow Microenvironment in Single Cell Resolution
Short Talk: Senescence Induction by the ATP-Gated P2X7 Receptor Limits T Cell Effector Response in the Tumor Microenvironment
Short Talk: Regulatory T Cells Promote Breast Cancer Progression and Metastasis by Functional Reprogramming of Bone Marrow-Derived Cell Populations
Short Talk: Targeting ACSS2 Inhibits HIF-2alpha Signaling and Stimulates the Anti-Tumor Immune Response in ccRCC
The Interplay between Slow-Cycling Chemoresistant Cancer Cells and Fibroblasts in Tumor Microenvironment Mediates Tumor Recurrence in Lung Cancer
Loss of p53 in Tumor Cells Promotes Immune-Tolerance through Modulation of the Innate and Adaptive Immune Responses
Kynurenine Metabolism in Cisplatin-Resistant Lung Cancer
Metabolic and Immune Regulatory Signatures in Chemoresistant Ovarian Cancer Stem Cells
Metabolic Endpoints as Biomarkers of Immune Checkpoint Therapy Response
Mitochondrial OXPHOS Activity Is Required for Lung Metastatic Colonization of Pancreatic Cancer
Mitochondrial Uncoupling Protein 2 (UCP2) Regulates T Cell Longevity and Anti-Tumor Function
Two-Stage Remodeling of Mitochondrial Metabolism in Macrophages Over a Course of Immune Response
Registered attendees can view abstracts starting on 02/15/2019
Angiogenesis Revisited: Role and (Therapeutic) Implications of Endothelial Metabolism
Metabolic Activity and Growth State in the Vascular Endothelium
Short Talk: Sialic Acid Metabolism Is a Key Driver of Breast Cancer Metastasis
Short Talk: Angiocrine Signals Promote Metastasis
Registered attendees can view abstracts starting on 02/15/2019
Therapeutics Targets in Cancer Metabolism
Dissecting the Impact of NRF2 Activation on Lung Adenocarcinoma Biology, Immune Contexture and Patient Outcomes
Constructing Tumor Vessels to Enhance Immunity
Short Talk: Understanding the Metabolome of Human TIL for Cancer Immunotherapy
Short Talk: Targeting Proline Availability in Metastatic Breast Cancer
Short Talk: A Metabolism-Triggered, Localized Payload Delivery System for T Cell Therapies
Registered attendees can view abstracts starting on 02/15/2019
Skin Stem Cells in Inflammation and Cancer
Cancer Targeted Therapy and Tumor Heterogeneity: Act Locally, Think Globally
Metastasis and the EMT
Short Talk: SOX4 Is Required for Maintaining Stem Cell Identity in Mammary Tumors
Short Talk: Elucidating the Role of Breast Cancer Stem Cells in Early Metastasis through Direct Visualization and Quantitation
Metabolic Symbioses in the Tumor Micorenvironment
Innate Immune and Metabolic Regulation of Metastatic Progression
Signaling and Metabolic Plasticity in the Process of Prostate Cancer Metastasis
Short Talk: Age-Induced Methylmalonic Acid Accumulation Promotes Cancer Progression and Metastasis Formation
Short Talk: Pyruvate Dehydrogenase: The Key to Epigenetic Regulation of Mammary CAFs
Short Talk: Using Mass Spectrometry Imaging to Identify Metabolic Adaptations during Metastasis of MYC-Driven Tumors
Registered attendees can view abstracts starting on 02/15/2019
Host-Microbe-Drug-Nutrient Interactions- A Holistic Approach for Cancer Treatment
The Gut Microbiome and PD-1 Therapy in Melanoma
Distinct Microbes, Metabolites and Ecologies Define the Microbiome in Deficient and Proficient Mismatch Repair Colorectal Cancers
Registered attendees can view abstracts starting on 02/15/2019
Keystone Symposia thanks our Sponsors for generously supporting this meeting:
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We gratefully acknowledge additional support from these exhibitors at this conference:
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We gratefully acknowledge additional support for this conference from:
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We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: Sarah Lavicka,
Director of Development, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org, Phone:+1 970-262-2676 |