Fairmont Empress Victoria Floorplan

Registered Attendees


Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:

  • Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting (You can edit your own abstract from My Account page as well)

    NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.

  • Full participant list, including joint meeting participants
  • Printable Invoices and Invitation Letters
  • Scholarship Information
  • Lodging Information

Login to My Account page

Genome Engineering: From Mechanisms to Therapies (B4)

Scientific Organizers: Andrew May, Rodolphe Barrangou and Knut Woltjen


February 19—23, 2019

Fairmont Empress Victoria, Victoria, British Columbia, Canada


Sponsored by BlueRock Therapeutics, Editas Medicine, Thermo Fisher Scientific Inc. and Vertex Pharmaceuticals Incorporated


Abstract submission is now closed. Registered attendees may bring a poster onsite. Please contact our office at +1 800-253-0685; +1 970-262-1230 or email info@keystonesymposia.org if you are interested.
BEWARE of booking lodging through companies unaffiliated with Keystone Symposia. Click here for more details.

Keystone Symposia is committed to maintaining a positive and respectful environment at its meetings. To this end, please review and comply with our policies.

DEADLINES:
*All deadlines end at 11:59 PM US Mountain Standard Time
Scholarship Deadline: Oct 23, 2018 [details]
Discounted Abstract Deadline: Oct 23, 2018 [details]
Abstract Deadline: Nov 20, 2018 [details]
Discounted Registration Deadline: Dec 19, 2018 [details]

If you have missed a deadline due to the US government shutdown, please contact our office.

Click here to view Cancellation Policy

Register Yourself Deadlines and Fees

Rates and Deadlines listed below are for the 2019-B4 "Genome Engineering: From Mechanisms to Therapies" conference only.

*All deadlines end at 11:59 PM US Mountain Standard Time

Deadline Date Cost
Discounted Abstract Deadline
More details
Before and On October 23, 2018 100.00 USD*
- 50.00 USD discount
Abstract Deadline
More details
After October 23, 2018 until January 8, 2019 100.00 USD*
* 50.00 USD of Abstract fee deducted from your registration fee when you register for this meeting
Scholarship
More details
October 23, 2018 n/a
Discounted NON-STUDENT Registration
More details
Before and On December 19, 2018 945.00 USD
(includes 200.00 discount)
Regular NON-STUDENT Registration
More details
After December 19, 2018 1145.00 USD
Discounted STUDENT Registration
More details
Before and On December 19, 2018 720.00 USD
(includes 200.00 discount)
Regular STUDENT Registration
More details
After December 19, 2018 920.00 USD

* Changes in payment type that result in a refund are subject to a processing fee.
* Currency exchange gains/losses are the responsibility of the registrant and the Keystone Symposia will accept no liability for money loss through bank charges, transfers or currency fluctuations.




Discounted Abstract Deadline: October 23, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time

Abstract Submission Fee: 100.00 USD*
Submission by this date receives 50.00 USD discount.
*50.00 USD will be applied to Registration Fee when you register

Abstract Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadlines. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract early allows us to:
  • submit your abstract to organizers to be considered for a short talk
  • accept your abstract online
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
(The Abstract Deadline: is November 20, 2018)

Global Health Travel Award Deadline:

*All deadlines end at 11:59 PM US Mountain Standard Time


Global Health Travel Award Details: You MUST complete your Global Health Travel Award appplication by the Global Health Travel Award Deadline and complete the other required steps (verify your contact information and submit a recommendation letter) to be considered for a travel award.


Click here to learn more about Global Health Travel Awards.

Scholarship Deadline: October 23, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Scholarship Details: You MUST submit your abstract by the Scholarship Deadline and complete the other required steps (submit a scholarship application and submit a mentor letter) to be considered for a scholarship.

Click here to learn more about Scholarships.

Abstract Deadline: November 20, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Abstract Submission Fee: 100.00 USD*
*50.00 USD will be applied to Registration Fee when you register

Details: It is best to submit your abstract early. Abstract and registration spaces are limited and may fill prior to the abstract or discounted registration deadline. Submitting an abstract does not constitute or guarantee registration.

Submitting your abstract by the Abstract Deadline allows us to:

  • submit your abstract to organizers to be considered for a short talk
  • include your abstract on our website and in our secure mobile app
  • reserve your space at the meeting for a poster presentation.**
**Submitting an abstract does not constitute or guarantee registration.
Abstracts submitted after the Abstract Deadline will NOT be considered for a short talk.

(Discounted Abstract Deadline: is October 23, 2018)

Discounted Registration Deadline: December 19, 2018

*All deadlines end at 11:59 PM US Mountain Standard Time


Registration Fee: 945.00 USD* (includes 200.00 USD discount)
Student Registration Fee: 720.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

After the Discounted Registration Deadline:


Registration Fee: 1145.00 USD*
Student Registration Fee: 920.00 USD* (must complete student verification form)

*Includes 50.00 USD of your abstract submission fee

Registration spaces are limited and may fill prior to discounted registration deadline.

Please be advised that some meeting participants have received calls and emails from a number of different housing services, including "Exhibitors Housing Services," “Expo Housing Services,” "Global Housing," etc. THESE COMPANIES ARE NOT AFFILIATED WITH KEYSTONE SYMPOSIA and are not authorized by Keystone Symposia to contact you. These companies may tell you that the meeting is filling, without any actual knowledge to that effect, and pressure you into giving them your credit card number to make a lodging reservation with them.

We highly recommend that you not make a reservation with these companies or any other housing service! These companies' representations to participants have been misleading. Please report any calls or correspondence you might have received to Keystone Symposia and book only through lodging links in your Keystone Symposia account, an established travel agency or directly with the hotel(s) listed on our website.
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Tuesday, February 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, February 23 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Sunday, February 24 in order to fully experience the meeting.

TUESDAY, FEBRUARY 19

16:00—20:00
Arrival and Registration

Palm Court
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Palm Court

WEDNESDAY, FEBRUARY 20

07:30—08:30
Breakfast

Palm Court
08:30—09:30
Welcome and Keynote Address
Registered attendees can view abstracts starting on 01/19/2019

Salon A
* Andrew May, Sana Biotechnology, Inc., USA

Philip D. Gregory, Bluebird Bio, USA
Toward Therapeutic Genome Editing: A Brief History (And Some Lessons Learned from Classical Gene Therapy)

09:30—11:45
Genome Engineering Tools and Technologies
Registered attendees can view abstracts starting on 01/19/2019

Salon A
* Dana Carroll, University of Utah School of Medicine, USA

Prashant Mali, University of California, San Diego, USA
Therapeutic Strategies via Genome Engineering: New Approaches and New Challenges

Coffee Break

Charles Gersbach, Duke University, USA
Epigenome Editing for Gene Therapy, Cell Programming and Functional Epigenomics

Alexis C. Komor, University of California, San Diego, USA
Using Uracil as a Genome Editing Intermediate

Peter Cameron, Caribou Biosciences, Inc., USA
Short Talk: Harnessing Type I CRISPR–Cas Systems for Human Genome Engineering

11:45—17:00
On Own for Lunch

11:45—13:00
Poster Setup

Salon B/C
13:00—22:00
Poster Viewing

Salon B/C
14:30—16:30
Workshop 1: Tools and Technologies

* Joanne Kamens, Addgene, USA

Abigail R. Lambert, Fred Hutchinson Cancer Research Center, USA
Structural and Functional Properties of Wild-Type and Engineered Meganucleases and MegaTALs

Henriette O'Geen, University of California, Davis, USA
Engineering Epigenetic Memory Requires Co-Targeting of Histone Methylatransferases and DNA Methylatransferases

Alister Funnell, Altius Institute for Biomedical Sciences, USA
Rapid Single-Cell Quantification of On- and Off-Target Nuclease Activity

Janin Grajcarek, Kyoto University, Japan
Identification of Microhomology-Flanked Deletion Mutations Across the Human Genome Enables Efficient Creation of Isogenic Disease Models in hiPSCs by CRISPR/Cas9

Hien Bao Dieu Thai, Korea Institute of Science and Technology, South Korea
DNAzymes-Based Tetrahedral Nanostructure for Enhanced Intracellular Gene-Silencing Activity

Brock Roberts, Allen Institute for Cell Science, USA
Systematic Gene Tagging to Illuminate Stem Cell Organization

16:30—17:00
Coffee Available

Prefunction 2
17:00—19:00
Structure and Mechanism of Genome Editing Systems
Registered attendees can view abstracts starting on 01/19/2019

Salon A
* Maria Jasin, Memorial Sloan Kettering Cancer Center, USA

Benjamin P. Kleinstiver, Massachusetts General Hospital, USA
Engineered CRISPR Nucleases to Enhance Genome Editing

Osamu Nureki, University of Tokyo, Japan
Molecular Mechanism of CRISPR and Structure-Based Development of Genome Editing Tool toward Medical Applications

Edward J. Rebar, Sangamo Therapeutics, Inc., USA
Short Talk: Optimizing Nuclease Specificity for Gene Editing via Tuning of Cleavage Kinetics Enables Complete Gene Modification with No Detectable Off-Targets

Amit Choudhary, Harvard Medical School, USA
Short Talk: Synthetic Activators, Inhibitors and Degraders of CRISPR-Associated Nucleases

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Salon B/C
19:30—22:00
Poster Session 1

Salon B/C

THURSDAY, FEBRUARY 21

07:30—08:30
Breakfast

Palm Court
08:00—08:30
Poster Setup

Salon B/C
08:30—17:00
Poster Viewing

Salon B/C
08:30—11:30
Engineered Models of Genetic Disease
Registered attendees can view abstracts starting on 01/19/2019

Salon A
* Bruce R. Conklin, University of California, San Francisco, USA

Danwei Huangfu, Memorial Sloan Kettering Cancer Institute, USA
Human Pluripotent Stem Cells as a Genetic Model for Human Development and Disease

Knut Woltjen, CiRA, Kyoto University, Japan
Precise Human Disease Allele Creation and Correction through Microhomology-Mediated End Joining

Coffee Break

Amy J. Wagers, Harvard University, USA
Gene Editing in Stem Cells

Erika Sasaki, Central Institute for Experimental Animals, Japan
Development of Genetically Modified Non-Human Primate Disease Models

Diogo Mosqueira, University of Nottingham, UK
Short Talk: CRISPR/Cas9 Genome Editing in Human Pluripotent Stem Cell-Cardiomyocytes to Model and Treat Hypertrophic Cardiomyopathy

11:30—12:30
Lunch

Salon B/C
12:00—14:30
Poster Session 2

Salon B/C
14:30—15:00
Coffee Available

Prefunction 2
15:00—17:00
Design and Engineering of Cellular Devices
Registered attendees can view abstracts starting on 01/19/2019

Salon A
* Alexis C. Komor, University of California, San Diego, USA

Wilson Wong, Boston University, USA
Mammalian Cell Design Using Synthetic Biology

Timothy K. Lu, Massachusetts Institute of Technology, USA
Synthetic Gene Circuits for Next-Generation Therapeutics

Zoltan Ivics, Paul Ehrlich Institute, Germany
Transposons: Molecular Parasites Tamed for Advanced Genome Engineering

Yale S. Michaels, University of Oxford, UK
Short Talk: A Generalizable Method for Precisely Tuning Gene Expression Levels in Mammalian Cells with Engineered MicroRNA Target Sites

17:00
On Own for Dinner


FRIDAY, FEBRUARY 22

07:30—08:30
Breakfast

Palm Court
08:30—11:30
Genome Editing Screens for Function and Disease Mechanisms
Registered attendees can view abstracts starting on 01/19/2019

Salon A
* Danwei Huangfu, Memorial Sloan Kettering Cancer Institute, USA

Fyodor D. Urnov, University of California, Berkeley, USA
Editing Human Genome Control Circuits to Reveal Disease Mechanisms and Targets for Intervention in the Clinic

Jan E. Carette, Stanford University, USA
CRISPR-Cas Screens for Studying Virus-Host Interactions

Coffee Break

Nozomu Yachie, University of Tokyo, Japan
Tracing Dynamics of Cells and Molecules using DNA Barcodes and Genome Editing

Britt S. Adamson, Princeton University, USA
Mapping the Processes of Genome Editing with High-Resolution Functional Genomics

11:30—12:30
Take the Bull by the Horns: Steps to a Fulfilling Career in Science
Registered attendees can view abstracts starting on 01/19/2019

* Joanne Kamens, Addgene, USA

11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Prefunction 2
17:00—19:15
Harnessing DNA Repair Mechanisms for Genome Engineering
Registered attendees can view abstracts starting on 01/19/2019

Salon A
* Britt S. Adamson, Princeton University, USA

Maria Jasin, Memorial Sloan Kettering Cancer Center, USA
Homologous Recombination and End-Joining Mechanisms in Genome Editing

Beeke Wienert, University of California, Berkeley, USA
Unbiased Detection of CRISPR Off-Targets in vivo using DISCOVER-Seq

Nancy Maizels, University of Washington School of Medicine, USA
Gene Correction at Targeted DNA Breaks

Andrew May, Sana Biotechnology, Inc., USA
DNA Repair Outcomes Provide Insight into Genome Editing Mechanisms in Primary Cell Systems

Tetsushi Sakuma, Hiroshima University, Japan
Short Talk: Concurrent MMEJ-Assisted Fusional Knock-In of Long Gene Cassette in Human Cells

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Salon C

SATURDAY, FEBRUARY 23

07:30—08:30
Breakfast

Palm Court
08:30—11:30
Genome Engineering of Bacteria for Therapeutic and Diagnostic Applications
Registered attendees can view abstracts starting on 01/19/2019

Salon A
* Andrew May, Sana Biotechnology, Inc., USA

Rodolphe Barrangou, North Carolina State University, USA
Engineering Lactobacilli for Human Health Applications

Jason M. Peters, University of Wisconsin-Madison, USA
Bacterial CRISPRi Screens to Identify the Mode of Action of Novel Antibiotics

Coffee Break

Richard P. Novick, New York University, USA
Conversion of Staphylococcal Pathogenicity Islands to CRISPR-Cas9-Based Antibacterial Drones

Joel Berry, Caribou Biosciences, USA
Short Talk: Utilizing CRISPR-Based Genome Editing for Microbiome Engineering

Akos Nyerges, Hungarian Academy of Sciences, Hungary
Short Talk: Predicting Antibiotic Resistance by Targeted Mutagenesis and Directed Evolution in Pathogenic Bacteria

David R. Edgell, University of Western Ontario, Canada
Short Talk: High Efficiency Inter-Species Conjugative Transfer of a CRISPR Nuclease for Targeted Bacterial Elimination

11:30—17:00
On Own for Lunch

14:30—16:30
Workshop 2: Delivery Methods
A collection of short talks chosen from the abstracts describing methods and approaches for in vitro and in vivo delivery of genome engineering technologies. The workshop would cover topics including devices for electroporation, mechanical introduction of molecules into cells, cell-specific targeting, viruses and viral-like particles, nanoparticles to address the key need to develop delivery vehicles for effective use of genome engineering approaches in therapeutics and research models.

Salon A
* Shondra M. Pruett-Miller, St. Jude Children’s Research Hospital, USA

Dana V. Foss, University of California, Berkeley, USA
Engineering Cas9 for T-Cell Specific Uptake and Therapeutic Genome Editing

Jacquelyn L S Hanson, SQZ Biotechnologies, USA
Microfluidic Delivery of Bioactive Molecules via SQZ Platform Enables Efficient T Cell Genome Engineering with Preserved Functionality

Lauren Elizabeth Woodard, Vanderbilt University, USA
Less Is More: How Less Recombinase Expression Produces More Genome-Modified Cells

Taisuke Kato, Niigata University, Japan
Gene Therapy for DRPLA Model Mice by AAV-Delivered CRISPR / Cas9

Eric Aird, University of Minnesota, USA
Enhancing HDR Efficiency by Tethering DNA to Cas9 via a Fused HUH Endonuclease

Erin Morgan, University of California, Santa Barbara, USA
Controlling the Genome: Light-Activated Delivery of Gene Editing Proteins and siRNA Allows for Up and Down Regulation of the Genome using Hollow Gold Nanoparticles

Masato Ohtsuka, Tokai University, Japan
i-GONAD: A Method for Generation of Genome-Edited Rodents without ex vivo Handling of Embryos

Anthony L. Forget, Intellia Therapeutics, USA
Supra-Therapeutic Levels of Transgene Expression Achieved in vivo by CRISPR/Cas9 Mediated Targeted Gene Insertion

16:30—17:00
Coffee Available

Prefunction 2
17:00—19:15
Genome Editing for Treating Human Disease
Registered attendees can view abstracts starting on 01/19/2019

Salon A
* Fyodor D. Urnov, University of California, Berkeley, USA

Bruce R. Conklin, University of California, San Francisco, USA
Using Patient-Derived iPSC Tissues to Model Precise Genome Surgery

Leonela Amoasii, Exonics Therapeutics, USA
Gene Editing Restores Dystrophin Expression in a Canine Model of Duchenne Muscular Dystrophy

Lukas Jeker, University of Basel, Switzerland
Short Talk: Repairing Foxp3 Mutations in T Cells Restores Regulatory T Cell Function

Jorge Mansilla-Soto, Memorial Sloan Kettering Cancer Center, USA
Advancing CAR-T Therapy with Precise Genome Engineering

Vic E. Myer, Editas Medicine, Inc., USA
Controlling Rearrangement Frequencies in the Context of Multigene Genome Editing

19:15—19:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Registered attendees can view abstracts starting on 01/19/2019

Salon A
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Palm Court/Crystal Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Palm Court/Crystal Ballroom

SUNDAY, FEBRUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



Keystone Symposia thanks our Sponsors for generously supporting this meeting:

BlueRock Therapeutics Editas Medicine
Thermo Fisher Scientific Inc. Vertex Pharmaceuticals Incorporated

We gratefully acknowledge additional support from these exhibitors at this conference:

Agilent Technologies, Inc. BEX CO., LTD.
Horizon Discovery MilliporeSigma
Synthego
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge additional support for this conference from:

American Society of Gene & Cell Therapy (ASGCT) Integrated DNA Technologies
Addgene
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



bluebird bio


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

CRISPR Journal, published by Mary Ann Liebert, Inc. publishers

Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Development, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org,
Phone:+1 970-262-2676