Keystone Resort Floorplan
Registered Attendees
Registered attendees (and speakers, organizers, etc.) will have access to the following items from their Account page:
- Abstracts from speakers and poster sessions, including the joint meeting abstracts, available 30 days prior to the meeting
(You can edit your own abstract from My Account page as well)
NOTE: Abstract authors/submitters may choose to not have their abstract available online and in the secure mobile app until a week before the meeting.
- Full participant list, including joint meeting participants
- Printable Invoices and Invitation Letters
- Scholarship Information
- Lodging Information
Login to My Account page
This meeting took place in 2019
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Molecular Approaches to Vaccines and Immune Monitoring (J5)
Organizer(s) Peter D. Kwong, Brandon DeKosky and Jeffrey B. Ulmer
February 10—14, 2019
Keystone Resort • Keystone, Colorado USA
Discounted Abstract Deadline: Oct 23, 2018
Abstract Deadline: Nov 7, 2018
Scholarship Deadline: Oct 23, 2018
Discounted Registration Deadline: Dec 6, 2018
Supported by Directors' Fund
Joint Meeting:
B Cell-T Cell Interactions (J6)
Summary of Meeting:
Vaccines address public health issues ranging from pandemic outbreaks to childhood disease. Despite this diversity, molecular approaches are beginning to find broad application. This Keystone Symposia conference seeks to bring together antibody aficionados, B cell immunologists, structural biologists, and vaccine developers from government, academia, biotechnology, and major pharmaceutical companies to review the utility of structure-based vaccine design and antibody-based immune monitoring, and in doing so hope to transform standard approaches of vaccine development. This meeting aims (1) to provide examples of the ”antibody-to-vaccine” paradigm for RSV, CMV and other pathogens that have resisted standard vaccinology; (2) to describe procedures whereby B cells can be taught to make the right antibodies; (3) to describe molecular approaches for vaccine improvement; and (4) to discuss how molecular approaches can be used to speed development (as may be needed, for example, in the case of pandemics) and to reduce developmental and regulatory costs (for vaccines in general and in particular to enable provision to the developing world). Overall, we seek to integrate molecular approaches for vaccine development and read-out with other transformative advances including mRNA delivery, next-generation sequencing of B cell transcripts, and control of B cell-T cell interactions. This conference will be held jointly with a Keystone Symposia conference on B Cell-T Cell Interactions and several shared sessions will highlight synergistic areas of research between these communities.
View Scholarships/Awards
Vaccines address public health issues ranging from pandemic outbreaks to childhood disease. Despite this diversity, molecular approaches are beginning to find broad application. This Keystone Symposia conference seeks to bring together antibody aficionados, B cell immunologists, structural biologists, and vaccine developers from government, academia, biotechnology, and major pharmaceutical companies to review the utility of structure-based vaccine design and antibody-based immune monitoring, and in doing so hope to transform standard approaches of vaccine development. This meeting aims (1) to provide examples of the ”antibody-to-vaccine” paradigm for RSV, CMV and other pathogens that have resisted standard vaccinology; (2) to describe procedures whereby B cells can be taught to make the right antibodies; (3) to describe molecular approaches for vaccine improvement; and (4) to discuss how molecular approaches can be used to speed development (as may be needed, for example, in the case of pandemics) and to reduce developmental and regulatory costs (for vaccines in general and in particular to enable provision to the developing world). Overall, we seek to integrate molecular approaches for vaccine development and read-out with other transformative advances including mRNA delivery, next-generation sequencing of B cell transcripts, and control of B cell-T cell interactions. This conference will be held jointly with a Keystone Symposia conference on B Cell-T Cell Interactions and several shared sessions will highlight synergistic areas of research between these communities.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 15 in order to fully experience the meeting.
SUNDAY, FEBRUARY 10
MONDAY, FEBRUARY 11
TUESDAY, FEBRUARY 12
WEDNESDAY, FEBRUARY 13
THURSDAY, FEBRUARY 14
FRIDAY, FEBRUARY 15
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 10 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 14 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 15 in order to fully experience the meeting.
SUNDAY, FEBRUARY 10
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Facundo D. Batista,
Ragon Institute of MGH, MIT and Harvard, USA
Antonio Lanzavecchia,
Institute for Research in Biomedicine, Switzerland
The B Cell Immune Response to Infection and Vaccination
The B Cell Immune Response to Infection and Vaccination
09:30—11:45
Targeting Appropriate Immune Responses for Structure-Based Design
Meeting has ended...abstracts no longer viewable online.
*
Gary J. Nabel,
Sanofi, USA
*
Erica Ollmann Saphire,
The Scripps Research Institute, USA
Dennis R. Burton,
The Scripps Research Institute, USA
From Antibody to Vaccine
From Antibody to Vaccine
George Georgiou,
University of Texas at Austin, USA
Molecular Definition of Protective Serum Responses from Vaccination and for Immune Monitoring
Molecular Definition of Protective Serum Responses from Vaccination and for Immune Monitoring
Peter D. Kwong,
NIAID, National Institutes of Health, USA
Antibody-Guided Structure-Based Vaccines: Challenges and Opportunities
Antibody-Guided Structure-Based Vaccines: Challenges and Opportunities
Evelien M. Bunnik,
University of Texas Health Science Center, USA
Short Talk: Naturally Acquired Protective Humoral Immunity Against Malaria
Short Talk: Naturally Acquired Protective Humoral Immunity Against Malaria
Nisreen Mamdouh Ahmed Okba,
Erasmus MC, Netherlands
Short Talk: Antibody Responses as Blueprint for MERS-CoV Rational Vaccine Design
Short Talk: Antibody Responses as Blueprint for MERS-CoV Rational Vaccine Design
Andrew McGuire,
Fred Hutchinson Cancer Research Center, USA
Short Talk: An Anti-gH/gL Antibody that Neutralizes Dual-Tropic Infection Defines a Site of Vulnerability on Epstein-Barr Virus
Short Talk: An Anti-gH/gL Antibody that Neutralizes Dual-Tropic Infection Defines a Site of Vulnerability on Epstein-Barr Virus
09:30—11:30
Tfh Biology
Meeting has ended...abstracts no longer viewable online.
Carola G. Vinuesa,
Australian National University, Australia
Human Tfh Biology
Human Tfh Biology
Hai Qi,
Tsinghua University, China
Guidance Cues for Tfh Cells
Guidance Cues for Tfh Cells
Shane Crotty,
La Jolla Institute for Allergy and Immunology, USA
Tfh Cell and Germinal Center B Cell Responses in the Context of Infections and Vaccines
Tfh Cell and Germinal Center B Cell Responses in the Context of Infections and Vaccines
*
Pamela L. Schwartzberg,
NIAID, NHGRI, National Institutes of Health, USA
Short Talk: PI3 Kinase-Mediated Pathways Orchestrate T and B Cell Contributions to Humoral Responses during Immunization and Infection
Short Talk: PI3 Kinase-Mediated Pathways Orchestrate T and B Cell Contributions to Humoral Responses during Immunization and Infection
Stephanie C. Eisenbarth,
Yale University, USA
Short Talk: A Unique Subset of Tfh Cells Drives High-Affinity IgE Production
Short Talk: A Unique Subset of Tfh Cells Drives High-Affinity IgE Production
14:30—16:30
Workshop 1: Molecular Design of Vaccines
*
Neil P. King,
University of Washington, USA
*
Guillaume B.E. Stewart-Jones,
National Institutes of Health, USA
Structure-Based Design of Nipah and Parainfluenza Virus F Glycoprotein Vaccines
Structure-Based Design of Nipah and Parainfluenza Virus F Glycoprotein Vaccines
Bruno Emanuel Correia,
École Polytechnique Fédérale de Lausanne, Switzerland
Trivalent Epitope-Focused Vaccine Elicits RSV Neutralization in NHPs
Trivalent Epitope-Focused Vaccine Elicits RSV Neutralization in NHPs
Timothy Caradonna,
Ragon Institute, USA
Molecular Grafting of a Complex Broadly Neutralizing Influenza Hemagglutinin Epitope
Molecular Grafting of a Complex Broadly Neutralizing Influenza Hemagglutinin Epitope
Syed M. Moin,
National Institutes of Health, USA
A Bi-Component Nanoparticle Presenting Group 1 and 2 Influenza Hemagglutinin Stem Trimers Confers Inter-Group Heterosubtypic Protections
A Bi-Component Nanoparticle Presenting Group 1 and 2 Influenza Hemagglutinin Stem Trimers Confers Inter-Group Heterosubtypic Protections
Seyhan Boyoglu-Barnum,
National Institutes of Health, USA
Computationally Designed Nanoparticles Displaying Influenza Virus Hemagglutinins of Seasonal Vaccine Strains
Computationally Designed Nanoparticles Displaying Influenza Virus Hemagglutinins of Seasonal Vaccine Strains
Cara Chao,
NIAID, National Institutes of Health, USA
An Isopeptide-Linking Platform to Incorporate Trimeric Antigens into Self-Assembling Nanoparticle Immunogens
An Isopeptide-Linking Platform to Incorporate Trimeric Antigens into Self-Assembling Nanoparticle Immunogens
Sean H. Kelly,
Duke University, USA
Molecular Design of Mucus-Penetrating Nanovaccines Enables Sublingual Peptide Immunization
Molecular Design of Mucus-Penetrating Nanovaccines Enables Sublingual Peptide Immunization
Kshitij Wagh,
Los Alamos National Laboratory, USA
A Novel Glycan Shield Prediction Strategy Reveals that HIV-1 Env Glycan Shield Completeness at Transmission Determines Development of Neutralization Breadth in Natural Infection
A Novel Glycan Shield Prediction Strategy Reveals that HIV-1 Env Glycan Shield Completeness at Transmission Determines Development of Neutralization Breadth in Natural Infection
14:30—16:30
Workshop 1: Biology of B Cell-T Cell Interactions
*
Dirk Baumjohann,
Ludwig-Maximilians-University Munich, Germany
T Cell-Expressed MicroRNAs Critically Regulate Germinal Center Tfh and B Cell Function and Maintenance
T Cell-Expressed MicroRNAs Critically Regulate Germinal Center Tfh and B Cell Function and Maintenance
Numana Bhat,
Sanford Burnham Prebys Medical Discovery Institute, USA
Regnase-1 Is Essential for Controlling Aberrant Differentiation of B Cells during Maturation and T Dependent B Cell Response
Regnase-1 Is Essential for Controlling Aberrant Differentiation of B Cells during Maturation and T Dependent B Cell Response
Takeshi Inoue,
Osaka University, Japan
Germinal-Center-Mediated Memory B Cell Development Is Driven by Cooperation of Metabolic Fitness and Survival
Germinal-Center-Mediated Memory B Cell Development Is Driven by Cooperation of Metabolic Fitness and Survival
Yisi Lu,
Yale University, USA
CD4+ Follicular Regulatory T Cells Improve the Protective Antigen-Specific Germinal Center B Cell Responses and Promote Memory
CD4+ Follicular Regulatory T Cells Improve the Protective Antigen-Specific Germinal Center B Cell Responses and Promote Memory
Laura Vella,
University of Pennsylvania/CHOP, USA
Cell States in the Thoracic Duct: Circulatory Intermediates of T Follicular Helper Cells between Lymph Nodes and Blood
Cell States in the Thoracic Duct: Circulatory Intermediates of T Follicular Helper Cells between Lymph Nodes and Blood
Tibor Z. Veres,
NIAID, National Institutes of Health, USA
Visualizing the Emerging Humoral Immune Response to Vaccines in 3D
Visualizing the Emerging Humoral Immune Response to Vaccines in 3D
Lea Simoni,
Boston Children's Hospital, USA
Role of C4A and C4B in SLE Susceptibility and Development
Role of C4A and C4B in SLE Susceptibility and Development
Hai-Hui (Howard) Xue,
University of Iowa, USA
Ezh2 Couples Epigenetic and Transcriptional Mechanism to Program Differentiation of Follicular Helper T Cells
Ezh2 Couples Epigenetic and Transcriptional Mechanism to Program Differentiation of Follicular Helper T Cells
17:00—19:00
Tackling Difficult Pathogens with Molecular-Based Vaccine Design
Meeting has ended...abstracts no longer viewable online.
*
Bruno Emanuel Correia,
École Polytechnique Fédérale de Lausanne, Switzerland
*
William Schief,
IAVI and The Scripps Research Institute, USA
Ian A. Wilson,
The Scripps Research Institute, USA
Towards a Universal Influenza Virus Vaccine: Is it Better to Target the HA Head or Stem?
Towards a Universal Influenza Virus Vaccine: Is it Better to Target the HA Head or Stem?
Sarah F. Andrews,
National Institutes of Health, USA
Identifying Common Antibody Lineages Elicited by Influenza Vaccination
Identifying Common Antibody Lineages Elicited by Influenza Vaccination
Erica Ollmann Saphire,
The Scripps Research Institute, USA
Broad-Spectrum Recognition of the Ebolaviruses
Broad-Spectrum Recognition of the Ebolaviruses
Andrew Flyak,
California Institute of Technology, USA
Short Talk: Common Genetic Signatures in HCV bNAbs: Implications for Vaccine Design
Short Talk: Common Genetic Signatures in HCV bNAbs: Implications for Vaccine Design
Johannes P.M. Langedijk,
Janssen Vaccines and Prevention, Netherlands
Short Talk: Stabilization of Conserved Metastable Structural Elements in Class I Fusion Proteins for Optimal Vaccine Design
Short Talk: Stabilization of Conserved Metastable Structural Elements in Class I Fusion Proteins for Optimal Vaccine Design
17:00—19:00
Regulation of the GC Response
Meeting has ended...abstracts no longer viewable online.
Andre Ballesteros-Tato,
University of Alabama at Birmingham, USA
IL-6 Stabilizes the GC-Tfh Cell Response to Influenza by Inhibiting IL-2 Responsiveness
IL-6 Stabilizes the GC-Tfh Cell Response to Influenza by Inhibiting IL-2 Responsiveness
*
Peter Sage,
Harvard Medical School, USA
Short Talk: TFR Cells Dynamically Regulate Distinct Stages of B Cell Responses
Short Talk: TFR Cells Dynamically Regulate Distinct Stages of B Cell Responses
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Hedda Wardemann,
German Cancer Research Center, Germany
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Antibody Responses and Antibodies
Antibody Responses and Antibodies
09:30—11:45
B Cell Ontogenies as Vaccine Templates
Meeting has ended...abstracts no longer viewable online.
*
Dennis R. Burton,
The Scripps Research Institute, USA
*
Andrew McGuire,
Fred Hutchinson Cancer Research Center, USA
Penny L. Moore,
University of the Witwatersrand and National Institute for Communicable Diseases, South Africa
Insight into Developing Immune Systems from Pediatric Studies of HIV Infection
Insight into Developing Immune Systems from Pediatric Studies of HIV Infection
William Schief,
IAVI and The Scripps Research Institute, USA
Germline-Targeting Vaccine Design
Germline-Targeting Vaccine Design
Frederick W. Alt,
Boston Children's Hospital, USA
Novel Mouse Models for Lineage-Based Vaccine Studies
Novel Mouse Models for Lineage-Based Vaccine Studies
Maya Sangesland,
Ragon Institute of MGH, MIT and Harvard, USA
Short Talk: Germline-Encoded Affinity Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies Against Influenza Virus
Short Talk: Germline-Encoded Affinity Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies Against Influenza Virus
Andrew J. Borst,
University of Washington, USA
Short Talk: Germline VRC01 Antibody Recognition of a Modified Clade C HIV-1 Envelope Trimer and a Glycosylated HIV-1 gp120 Core
Short Talk: Germline VRC01 Antibody Recognition of a Modified Clade C HIV-1 Envelope Trimer and a Glycosylated HIV-1 gp120 Core
Amelia Escolano,
Rockefeller University, USA
Short Talk: Prime Immunization Expands Precursors of Anti HIV-1 Broadly Neutralizing Antibodies in Mice, Rabbits and Rhesus Macaques
Short Talk: Prime Immunization Expands Precursors of Anti HIV-1 Broadly Neutralizing Antibodies in Mice, Rabbits and Rhesus Macaques
09:30—11:30
Germinal Center Biology
Meeting has ended...abstracts no longer viewable online.
Jason G. Cyster,
HHMI/University of California, San Francisco, USA
Germinal Center B Cell Confinement Mechanisms
Germinal Center B Cell Confinement Mechanisms
Tomohiro Kurosaki,
WPI Immunology Frontier Research Center, Osaka University, Japan
Selection Mechanisms of Germinal Center Cells into the Memory B Cell Compartment
Selection Mechanisms of Germinal Center Cells into the Memory B Cell Compartment
*
Kim Good-Jacobson,
Monash University, Australia
Short Talk: Humoral Responses to Chronic Viral and Parasitic Infection are Underpinned by Dysregulation of the Polycomb Repressive Complexes
Short Talk: Humoral Responses to Chronic Viral and Parasitic Infection are Underpinned by Dysregulation of the Polycomb Repressive Complexes
Mark R. Boothby,
Vanderbilt University Medical Center, USA
Short Talk: Imaging & Manipulating Nutrient Micro-Milieux as B Cells Effect Humoral Immunity
Short Talk: Imaging & Manipulating Nutrient Micro-Milieux as B Cells Effect Humoral Immunity
14:30—16:30
Workshop 2: Antibody Characterization and B Cell Sequencing
*
Antonio Lanzavecchia,
Institute for Research in Biomedicine, Switzerland
*
Laura M. Walker,
Adimab LLC, USA
Kathryn Hastie,
The Scripps Research Institute, USA
Convergent Structures Reveal Key Residues to Enhance Potency and Breadth for Pan-Lassa Virus Neutralization
Convergent Structures Reveal Key Residues to Enhance Potency and Breadth for Pan-Lassa Virus Neutralization
Jonathan McDaniel,
University of Texas at Austin, USA
R21 Vaccine Elicits Near Germline Serum Antibodies that Potently Inhibit Malaria Infection
R21 Vaccine Elicits Near Germline Serum Antibodies that Potently Inhibit Malaria Infection
Lan Zhang,
Merck, USA
Characterization of Potent RSV Neutralizing Antibodies Isolated from Human Memory B Cells and Identification of a Novel RSV/hMPV Cross-Neutralizing Epitope
Characterization of Potent RSV Neutralizing Antibodies Isolated from Human Memory B Cells and Identification of a Novel RSV/hMPV Cross-Neutralizing Epitope
Bharat Madan,
University of Kansas, USA
In vitro Evolution of a Vaccine-Elicited Antibody Identifies New Capabilities for Effective Fusion Peptide-Based HIV Neutralization
In vitro Evolution of a Vaccine-Elicited Antibody Identifies New Capabilities for Effective Fusion Peptide-Based HIV Neutralization
Lauren E. Gentles,
University of Washington, USA
Complete Antigenic Mapping of an Influenza A Virus Non-Neutralizing Antibody
Complete Antigenic Mapping of an Influenza A Virus Non-Neutralizing Antibody
Goran Bajic,
Harvard Medical School, USA
Autoreactivity Profiles of Influenza Hemagglutinin Broadly Neutralizing Antibodies
Autoreactivity Profiles of Influenza Hemagglutinin Broadly Neutralizing Antibodies
Pablo Canales Herrerias,
Institut Pasteur, France
Characterizing Autoantibody-Producing Cells in Thrombocytopenic Patients for Secretion Rate and Affinity for a Platelet Autoantigen
Characterizing Autoantibody-Producing Cells in Thrombocytopenic Patients for Secretion Rate and Affinity for a Platelet Autoantigen
Karyn McFadden,
Amgen, USA
Rapid Discovery of Functional Antibodies from Primary Cells using an Optofluidic Single-Cell Screening Platform
Rapid Discovery of Functional Antibodies from Primary Cells using an Optofluidic Single-Cell Screening Platform
14:30—16:30
Workshop 2: B and T Cell Responses in the Mucosa
Yoshimasa Takahashi,
National Institute of Infectious Diseases, Japan
Local Germinal Center B Cells Target Conserved Epitopes that Are Occluded in Native Viral Antigen
Local Germinal Center B Cells Target Conserved Epitopes that Are Occluded in Native Viral Antigen
Adi Biram,
Weizmann Institute of Science, Israel
Differential Roles for B Cell Receptor Affinity in Colonization of the Subepithelial Dome and Infiltration into Pre-Existing Germinal Centers within Peyer's Patches
Differential Roles for B Cell Receptor Affinity in Colonization of the Subepithelial Dome and Infiltration into Pre-Existing Germinal Centers within Peyer's Patches
Rebecca A. Elsner,
University of Pittsburgh, USA
IL-12 Production during Salmonella Infection Suppresses T Follicular Helper Cell Differentiation
IL-12 Production during Salmonella Infection Suppresses T Follicular Helper Cell Differentiation
Steven Erickson,
University of Chicago, USA
Polyreactive B Cells in the Mucosa
Polyreactive B Cells in the Mucosa
Raud Razzaghi,
National Institutes of Health, USA
Regulation of Fas-Mediated Apoptosis in Mucosal Germinal Center B Cells
Regulation of Fas-Mediated Apoptosis in Mucosal Germinal Center B Cells
Jacqueline H.Y. Siu,
Cambridge University, UK
Investigating Non-Conventional Memory B Cells in Human Lymphoid Tissues
Investigating Non-Conventional Memory B Cells in Human Lymphoid Tissues
Marisa Stebegg,
University of Cambridge, UK
Faecal Microbiota Transplantation Restores the Reduced Germinal Centre Response in Peyer's Patches of Aged Mice
Faecal Microbiota Transplantation Restores the Reduced Germinal Centre Response in Peyer's Patches of Aged Mice
*
Duane R. Wesemann,
Harvard Medical School, USA
Naïve Ig Repertoire Polyreactivity Is a Tunable Feature
Naïve Ig Repertoire Polyreactivity Is a Tunable Feature
17:00—19:00
Clinical Results from Molecular-Based Vaccines
Meeting has ended...abstracts no longer viewable online.
*
Julie Ledgerwood,
NIAID, National Institutes of Health, USA
*
Drew Weissman,
University of Pennsylvania, USA
Sumana Chandramouli,
GlaxoSmithKline Vaccines, USA
A Structural Biology Approach to Developing an HCMV Vaccine
A Structural Biology Approach to Developing an HCMV Vaccine
Amy S. Espeseth,
Merck & Co., USA
mRNA Vaccines Expressing Forms of RSV-F Protein Are Immunogenic and Protective in Preclinical Models of Respiratory Syncytial Virus Infection
mRNA Vaccines Expressing Forms of RSV-F Protein Are Immunogenic and Protective in Preclinical Models of Respiratory Syncytial Virus Infection
Barney S. Graham,
NIAID, National Institutes of Health, USA
Clinical Results from the Prefusion-Stabilized RSV F (DS-Cav1) Subunit Vaccine
Clinical Results from the Prefusion-Stabilized RSV F (DS-Cav1) Subunit Vaccine
Katherine Burgomaster,
NIAID, National Institutes of Health, USA
Short Talk: Limited Cross-Reactive Antibody Responses Elicited by a ZIKV DNA Vaccine Candidate
Short Talk: Limited Cross-Reactive Antibody Responses Elicited by a ZIKV DNA Vaccine Candidate
Adrian V. S. Hill,
Jenner Institute, University of Oxford, UK
Short Talk: Enhanced Efficacy of Anti-Liver-Stage Vectored Vaccines using a Prime-Target Immunisation Approach
Short Talk: Enhanced Efficacy of Anti-Liver-Stage Vectored Vaccines using a Prime-Target Immunisation Approach
17:00—19:00
B Cells and Helper T Cells Outside of B Cell Follicles
Meeting has ended...abstracts no longer viewable online.
Ziv Shulman,
Weizmann Institute, Israel
Syk Proteasomal Degradation Regulates B Cell Fate in Germinal Centers
Syk Proteasomal Degradation Regulates B Cell Fate in Germinal Centers
Troy D. Randall,
University of Alabama at Birmingham, USA
Lung-Resident Memory B Cells
Lung-Resident Memory B Cells
Jason Weinstein,
Rutgers New Jersey Medical School, USA
Short Talk: STAT4 Regulates Pathogenic IL-21 and IFN-γ Production in T Follicular Helper (Tfh) Cells in Murine and Human Lupus
Short Talk: STAT4 Regulates Pathogenic IL-21 and IFN-γ Production in T Follicular Helper (Tfh) Cells in Murine and Human Lupus
*
Tullia C. Bruno,
University of Pittsburgh, USA
Short Talk: Tumor-Infiltrating B Cells Co-Localize with CD4 T Effector Cells within Tertiary Lymphoid Structures to Present Antigen and Educate the Anti-Tumor Immune Response in Human Primary Tumors
Short Talk: Tumor-Infiltrating B Cells Co-Localize with CD4 T Effector Cells within Tertiary Lymphoid Structures to Present Antigen and Educate the Anti-Tumor Immune Response in Human Primary Tumors
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Keynote Session (Joint)
Meeting has ended...abstracts no longer viewable online.
*
Michel C. Nussenzweig,
HHMI/Rockefeller University, USA
Facundo D. Batista,
Ragon Institute of MGH, MIT and Harvard, USA
Importance of B Cell-T Cell Interactions in Mouse Vaccine Models
Importance of B Cell-T Cell Interactions in Mouse Vaccine Models
Hedda Wardemann,
German Cancer Research Center, Germany
Development and Clonal Evolution of Human Memory B Cell Antibody Responses
Development and Clonal Evolution of Human Memory B Cell Antibody Responses
10:00—11:45
Immune Monitoring of B Cell Responses
Meeting has ended...abstracts no longer viewable online.
*
Frederick W. Alt,
Boston Children's Hospital, USA
*
Brandon DeKosky,
University of Kansas, USA
Michael Joseph Mina,
Brigham and Women's Hospital / Harvard Medical School / School of Public Health, USA
Comprehensive Profiling of the Anti-Pathogen Antibody Repertoire with Phage Display and Deep Neural Networks for Infectious Disease and Vaccine Surveillance
Comprehensive Profiling of the Anti-Pathogen Antibody Repertoire with Phage Display and Deep Neural Networks for Infectious Disease and Vaccine Surveillance
Margaret Ellen Ackerman,
Dartmouth College, USA
Measuring and Mining Serum Antibody Responses to Understand Protection from Infection
Measuring and Mining Serum Antibody Responses to Understand Protection from Infection
Gwo-Yu Chuang,
NIAID, National Institutes of Health, USA
Short Talk: Delineating the Sequence Signature of a Multi-Donor Class of Human Antibodies that Broadly Neutralizes Influenza Viruses for Immune Monitoring of Vaccination Studies
Short Talk: Delineating the Sequence Signature of a Multi-Donor Class of Human Antibodies that Broadly Neutralizes Influenza Viruses for Immune Monitoring of Vaccination Studies
Colin Havenar-Daughton,
La Jolla Institute for Immunology, USA
Short Talk: Longitudinally Tracked, Rapid, Robust Antigen-Specific Germinal Center Responses and Somatic Hypermutation in Non-Human Primates After a Single Nanoparticle Vaccine Immunization
Short Talk: Longitudinally Tracked, Rapid, Robust Antigen-Specific Germinal Center Responses and Somatic Hypermutation in Non-Human Primates After a Single Nanoparticle Vaccine Immunization
David B. Weiner,
Wistar Institute, USA
Short Talk: Immunogenicity and Protection with A Low-Dose Intradermal Vaccine INO-4700 Against Middle East Respiratory Syndrome in Non-Human Primates
Short Talk: Immunogenicity and Protection with A Low-Dose Intradermal Vaccine INO-4700 Against Middle East Respiratory Syndrome in Non-Human Primates
10:00—11:30
B Cell Responses in Infectious Disease
Meeting has ended...abstracts no longer viewable online.
Patrick C. Wilson,
University of Chicago, USA
The B Cell Response to Influenza and Vaccination
The B Cell Response to Influenza and Vaccination
Katherine Kedzierska,
University of Melbourne, Australia
B Cell and T Follicular Helper Cell Responses during Influenza Virus Infection and Vaccination
B Cell and T Follicular Helper Cell Responses during Influenza Virus Infection and Vaccination
*
Ian A. Cockburn,
Australian National University, Australia
Short Talk: Chronic Antigen Exposure and Potent Antibody Feedback Limit Memory Responses to a Major Malaria Vaccine Candidate
Short Talk: Chronic Antigen Exposure and Potent Antibody Feedback Limit Memory Responses to a Major Malaria Vaccine Candidate
Daniel Lingwood,
Havard Medical School, USA
Short Talk: Natural Gene-Encoded Affinity for Cognate Antigen Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies against Influenza Virus
Short Talk: Natural Gene-Encoded Affinity for Cognate Antigen Facilitates Vaccine-Amplification of Broadly Neutralizing Antibodies against Influenza Virus
14:30—16:30
Workshop 3: Molecular Probing of the Elicited Vaccine Response
*
Pierre Bruhns,
Institut Pasteur, France
*
George Georgiou,
University of Texas at Austin, USA
Maryam Mukhamedova,
NIAID, National Institutes of Health, USA
Characterization of RSV Antibody Repertoire to B Cells Elicited by Prefusion RSV F Subunit Protein (DS-Cav1)-Vaccinated Adult Volunteers
Characterization of RSV Antibody Repertoire to B Cells Elicited by Prefusion RSV F Subunit Protein (DS-Cav1)-Vaccinated Adult Volunteers
Raffaello Verardi,
NIAID, National Institutes of Health, USA
Structural Studies of Human Norovirus Antibodies Isolated from Vaccines Reveal Basis for Broad Reactivity
Structural Studies of Human Norovirus Antibodies Isolated from Vaccines Reveal Basis for Broad Reactivity
Christopher Andrew Cottrell,
The Scripps Research Institute, USA
Immunofocusing Antibody Responses to Target the HIV Env Fusion Peptide (FP) Epitope in Non-Human Primates (NHPs)
Immunofocusing Antibody Responses to Target the HIV Env Fusion Peptide (FP) Epitope in Non-Human Primates (NHPs)
Zizhang Sheng,
Columbia University, USA
Developmental Pathways for Vaccine-Induced Neutralizing Antibodies Targeting the HIV-1 Fusion Peptide Suggest a Low Barrier to Elicitation
Developmental Pathways for Vaccine-Induced Neutralizing Antibodies Targeting the HIV-1 Fusion Peptide Suggest a Low Barrier to Elicitation
Rajagopal Murugan,
German Cancer Research Institute, Germany
Maturation of the Memory B Cell Response to Plasmodium Falciparum Circumsporozoite Protein (PfCSP) through Clonal Selection, Not Affinity Maturation
Maturation of the Memory B Cell Response to Plasmodium Falciparum Circumsporozoite Protein (PfCSP) through Clonal Selection, Not Affinity Maturation
Elisabetta Frigimelica,
GlaxoSmithKline Vaccines S.r.l., Italy
Characterization of the Human Antibody Repertoire Following Immunization with Meningococcus B Vaccine
Characterization of the Human Antibody Repertoire Following Immunization with Meningococcus B Vaccine
Murillo Silva,
Massachusetts Institute of Technology, USA
Saponin-MPLA Nanoparticulate Adjuvants Alter Lymph Flow and Enhance Early Antigen Acquisition by B Cells
Saponin-MPLA Nanoparticulate Adjuvants Alter Lymph Flow and Enhance Early Antigen Acquisition by B Cells
14:30—16:30
Workshop 3: B Cell-T Cell Interactions in Disease
Davide Angeletti,
University of Gothenburg, Sweden
Outflanking B Cell and Antibody Immunodominance to Target Subdominant Influenza A Virus Epitopes
Outflanking B Cell and Antibody Immunodominance to Target Subdominant Influenza A Virus Epitopes
Rachael Bashford-Rogers,
University of Oxford, UK
Mapping B Cell Receptor Repertoires in Six Immune-Mediated Diseases
Mapping B Cell Receptor Repertoires in Six Immune-Mediated Diseases
Blair L. DeBuysscher,
Fred Hutchinson Cancer Research Center, USA
Mapping the HIV Envelope-Specific B Cell Population in HIV-Unexposed Individuals
Mapping the HIV Envelope-Specific B Cell Population in HIV-Unexposed Individuals
Marco De Giovanni,
Ospedale San Raffaele Srl, Italy
Spatiotemporal Regulation of Type I Interferon Determines Antiviral CD4+ T Cell Polarization
Spatiotemporal Regulation of Type I Interferon Determines Antiviral CD4+ T Cell Polarization
*
Joanna R. Groom,
Walter and Eliza Hall Institute of Medical Research, Australia
TFH/TH1 Common Precursor Requires CXCR3-Dependent Interactions at the T:B Boarder
TFH/TH1 Common Precursor Requires CXCR3-Dependent Interactions at the T:B Boarder
Shi-Hsia Hwa,
Africa Health Research Institute, South Africa
Effects of Monoclonal Antibodies from TB Patient Lymph Node and Healthy Donor Blood on Mycobacterium tuberculosis Growth and Macrophage Infection
Effects of Monoclonal Antibodies from TB Patient Lymph Node and Healthy Donor Blood on Mycobacterium tuberculosis Growth and Macrophage Infection
Amber Papillion,
University of Alabama, USA
Interleukin 6 Prevents the Premature Contraction of the T Follicular Helper (Tfh) Cell Response to Influenza by Precluding IL-2 Responsiveness of GC-Tfh Cells
Interleukin 6 Prevents the Premature Contraction of the T Follicular Helper (Tfh) Cell Response to Influenza by Precluding IL-2 Responsiveness of GC-Tfh Cells
William T. Yewdell,
Memorial Sloan Kettering Cancer Center, USA
Striking Features of the Memory B Cell Response to Influenza Infection
Striking Features of the Memory B Cell Response to Influenza Infection
17:00—19:00
Optimizing Vaccine Responses
Meeting has ended...abstracts no longer viewable online.
*
Peter D. Kwong,
NIAID, National Institutes of Health, USA
*
Ian A. Wilson,
The Scripps Research Institute, USA
Neil P. King,
University of Washington, USA
Computational Design of Protein Nanomaterials for Next-Generation Vaccine Design
Computational Design of Protein Nanomaterials for Next-Generation Vaccine Design
Günther Staffler,
AFFiRiS AG, Austria
Towards a Heart Attack Vaccine: PCSK9 as a Immunogen
Towards a Heart Attack Vaccine: PCSK9 as a Immunogen
Sonia M. Maciejewski,
NIAID, National Institutes of Health, USA
Short Talk: Distinct Correlates of Protection Among Closely Related ZIKV DNA Vaccines Identify a Critical Role for Antibody Quality Following Vaccination
Short Talk: Distinct Correlates of Protection Among Closely Related ZIKV DNA Vaccines Identify a Critical Role for Antibody Quality Following Vaccination
Kimberly M. Cirelli,
La Jolla Institute for Allergy and Immunology, USA
Short Talk: Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance
Short Talk: Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance
17:00—19:00
Memory Humoral Responses
Meeting has ended...abstracts no longer viewable online.
Marc K. Jenkins,
University of Minnesota Medical School, USA
Memory T and B Cell Responses
Memory T and B Cell Responses
Mark J. Shlomchik,
University of Pittsburgh School of Medicine, USA
Heterogeneity of Memory B Cell Compartments
Heterogeneity of Memory B Cell Compartments
Marion Pepper,
University of Washington, USA
Memory B Cells in Plasmodium Infection
Memory B Cells in Plasmodium Infection
*
Claude-Agnès Reynaud,
Necker-Paris Medical School, France
Short Talk: A Splenic IgM Memory Subset Harboring Anti-Bacterial Specificities is Sustained from Persistent Mucosal Germinal Center Reactions
Short Talk: A Splenic IgM Memory Subset Harboring Anti-Bacterial Specificities is Sustained from Persistent Mucosal Germinal Center Reactions
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Vaccines: Better, Faster and Less Expensive!
Meeting has ended...abstracts no longer viewable online.
*
Amy S. Espeseth,
Merck & Co., USA
*
Barney S. Graham,
NIAID, National Institutes of Health, USA
Rino Rappuoli,
GlaxoSmithKline Vaccines, Italy
Developing Vaccines against Pandemics and for the Developing World
Developing Vaccines against Pandemics and for the Developing World
Laura M. Walker,
Adimab LLC, USA
Generation of Broad and Potent Neutralizing Antibodies to Speed Pandemic Responses
Generation of Broad and Potent Neutralizing Antibodies to Speed Pandemic Responses
Coffee Break
*
Jeffrey B. Ulmer,
GlaxoSmithKline Vaccines, USA
*
David B. Weiner,
Wistar Institute, USA
Brandon DeKosky,
University of Kansas, USA
Paired Heavy-Light Chain Sequencing and Display for Immune Monitoring of Vaccination and Natural Infection
Paired Heavy-Light Chain Sequencing and Display for Immune Monitoring of Vaccination and Natural Infection
Julie Ledgerwood,
NIAID, National Institutes of Health, USA
Immune Monitoring to Increase the Likelihood of Phase 2 Success
Immune Monitoring to Increase the Likelihood of Phase 2 Success
Ami Patel,
Wistar Institute, USA
Short Talk: Infection to Protection: An in vivo Approach for Rapid Delivery of DNA-Encoded Monoclonal Antibodies (DMAbs) Isolated Directly from Ebola Virus Disease Survivors and Other Infectious Diseases
Short Talk: Infection to Protection: An in vivo Approach for Rapid Delivery of DNA-Encoded Monoclonal Antibodies (DMAbs) Isolated Directly from Ebola Virus Disease Survivors and Other Infectious Diseases
Julia Lederhofer,
NIAID, National Institutes of Health, USA
Short Talk: Augmented Immune Responses by Co-Immunization of Commercial Seasonal Influenza Vaccine and the HA Stem-Based Universal Influenza Vaccine Candidates
Short Talk: Augmented Immune Responses by Co-Immunization of Commercial Seasonal Influenza Vaccine and the HA Stem-Based Universal Influenza Vaccine Candidates
Daniel R. Ellis,
University of Washington, USA
Short Talk: Co-Display of Multiple Antigenic Variants on Computationally-Designed Protein Nanomaterials as a Versatile Vaccine Platform
Short Talk: Co-Display of Multiple Antigenic Variants on Computationally-Designed Protein Nanomaterials as a Versatile Vaccine Platform
08:00—11:00
Humoral Autoimmunity and Allergic Responses
Meeting has ended...abstracts no longer viewable online.
Rachel Ettinger,
Viela Bio, USA
VIB4920, a Novel CD40L Antagonist, Decreased Disease Activity and Improved Biomarkers of Immune Activation in a Phase 1b, Proof-of-Concept Study in Rheumatoid Arthritis
VIB4920, a Novel CD40L Antagonist, Decreased Disease Activity and Improved Biomarkers of Immune Activation in a Phase 1b, Proof-of-Concept Study in Rheumatoid Arthritis
Michael C. Carroll,
Boston Children's Hospital, Harvard Medical School, USA
Epitope Spreading in Autoimmune Germinal Centers
Epitope Spreading in Autoimmune Germinal Centers
Coffee Break
*
Maria A. Curotto de Lafaille,
New York University School of Medicine, USA
Biology of IgE Affinity Maturation
Biology of IgE Affinity Maturation
Christopher C. Goodnow,
Garvan Institute of Medical Research, Australia
Progression from Benign to Pathogenic Autoantibody by Somatic Mutation in a Rogue Clone: Single Cell RNA and DNA Sequencing
Progression from Benign to Pathogenic Autoantibody by Somatic Mutation in a Rogue Clone: Single Cell RNA and DNA Sequencing
Fleur du Pre,
University of Oslo and Oslo University Hospital, Norway
Short Talk: A Celiac Disease Patient-Derived Anti-TG2 Antibody Is not Tolerized in Mice
Short Talk: A Celiac Disease Patient-Derived Anti-TG2 Antibody Is not Tolerized in Mice
Brigette Boast,
Australian National University, Australia
Short Talk: ARPC1B-/- Mice Suggest a New Role for DOCK8 in the Murine Germinal Center Response
Short Talk: ARPC1B-/- Mice Suggest a New Role for DOCK8 in the Murine Germinal Center Response
17:00—18:45
Reducing Vaccine Risks and Costs
Meeting has ended...abstracts no longer viewable online.
*
Margaret Ellen Ackerman,
Dartmouth College, USA
*
Rino Rappuoli,
GlaxoSmithKline Vaccines, Italy
Jeffrey B. Ulmer,
GlaxoSmithKline Vaccines, USA
Molecular Approaches to Streamlining Vaccine Discovery and Development
Molecular Approaches to Streamlining Vaccine Discovery and Development
Drew Weissman,
University of Pennsylvania, USA
Advantages of an mRNA Vaccine Approach
Advantages of an mRNA Vaccine Approach
Gary J. Nabel,
Sanofi, USA
Innovation in Antibody Structure and Design to Optimize Protection and Improve Efficacy: Vaccine Implications
Innovation in Antibody Structure and Design to Optimize Protection and Improve Efficacy: Vaccine Implications
17:00—18:45
T-Dependent B Cell Differentiation
Meeting has ended...abstracts no longer viewable online.
Brian J. Laidlaw,
University of California, San Francisco, USA
Short Talk: Transcriptional Regulation of Memory B Cell Development Following Viral Infection
Short Talk: Transcriptional Regulation of Memory B Cell Development Following Viral Infection
Meinrad Busslinger,
Research Institute of Molecular Pathology, Austria
Ikaros Prevents Autoimmunity by Promoting Anergy Induction and Restraining Toll-Like Receptor Signaling in B Cells
Ikaros Prevents Autoimmunity by Promoting Anergy Induction and Restraining Toll-Like Receptor Signaling in B Cells
Robert Brink,
Garvan Institute of Medical Research, Australia
Constant Region-Based Selection in the Germinal Center Reaction
Constant Region-Based Selection in the Germinal Center Reaction
*
Kai-Michael Toellner,
University of Birmingham Medical School, UK
Short Talk: CCL19/CCL21 Direct Memory B Cell Reentry in Reactive Lymph Nodes
Short Talk: CCL19/CCL21 Direct Memory B Cell Reentry in Reactive Lymph Nodes
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Meeting has ended...abstracts no longer viewable online.
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge additional support from these exhibitors at this conference:
|
|
Please stop by to meet these exhibitors during the conference.
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
|
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: Sarah Lavicka,
Director of Development, Email: sarahl@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Yvonne Psaila, Director, Marketing and Communications, Email: yvonnep@keystonesymposia.org, Phone:+1 970-262-2676 |
